CHRONIC MYELOGENOUS LEUKEMIA

A very detailed research report on chronic mylogenpus leukemia for and undergraduate level understamding of the subject . Chronic myelogenous leukemia is a clonal stem cell disorder characterized by increased proliferation of myeloid elements at all stages of differentiation. CML is one of the few cancers known to be caused by a single, specific genetic mutation. The disease is characterized by insidious onset of symptoms, progressive splenomegaly, anemia, leukocytosis and cytogenetically by the presence of Philadelphia chromosome in 90-95% of patients.